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simulations matlab simbiology 2018  (MathWorks Inc)
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Fig. 2. In vivo Near Infrared Imaging following Subcutaneous Administration. C57/black mice were administered SA + saline, SA-bNP or bNP + saline SC into the right footpad ( n = 3 each group). Injection volume was 40 μL in each group through a 28G needle. SA was loaded onto bNPs by incubation with an approximately 2x molar excess of SA: bNP surface biotin for 30 minutes. Unbound SA was washed from particles by centrifugation and decanting supernatant 2x. SA + saline was injected at the calculated maximum biotin binding on bNPs. T = 0 SA + saline dose was higher than SA-bNP dose due to incomplete binding of SA on bNP and washing steps to remove unbound SA. Observed fluorescence in the 700 nm channel for SA + saline (A) and SA in SA-bNP (B), and in the 800nm channel for bNP in SA-bNP (C) and unloaded bNPs (D). Normalized injection site elimination profiles vs time for SA + Saline (E ), SA in SA-bNP (F) bNP in SA-bNP (G ), and bNP + saline (H). I, Elimination rate constants from injection site. Data was fitted to a 1-compartment PK model utilizing <t>Matlab</t> symbiology. J, Area under the curve for free and bound SA in the injection site were calculated from concentration vs time data. ∗, ∗∗, ∗∗∗p < 0.05, < 0.01, and < 0.001 respectively, by 1-way ANOVA or two-tailed T-test.
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Fig. 2. In vivo Near Infrared Imaging following Subcutaneous Administration. C57/black mice were administered SA + saline, SA-bNP or bNP + saline SC into the right footpad ( n = 3 each group). Injection volume was 40 μL in each group through a 28G needle. SA was loaded onto bNPs by incubation with an approximately 2x molar excess of SA: bNP surface biotin for 30 minutes. Unbound SA was washed from particles by centrifugation and decanting supernatant 2x. SA + saline was injected at the calculated maximum biotin binding on bNPs. T = 0 SA + saline dose was higher than SA-bNP dose due to incomplete binding of SA on bNP and washing steps to remove unbound SA. Observed fluorescence in the 700 nm channel for SA + saline (A) and SA in SA-bNP (B), and in the 800nm channel for bNP in SA-bNP (C) and unloaded bNPs (D). Normalized injection site elimination profiles vs time for SA + Saline (E ), SA in SA-bNP (F) bNP in SA-bNP (G ), and bNP + saline (H). I, Elimination rate constants from injection site. Data was fitted to a 1-compartment PK model utilizing Matlab symbiology. J, Area under the curve for free and bound SA in the injection site were calculated from concentration vs time data. ∗, ∗∗, ∗∗∗p < 0.05, < 0.01, and < 0.001 respectively, by 1-way ANOVA or two-tailed T-test.

Journal: Acta biomaterialia

Article Title: Modeling the kinetics of lymph node retention and exposure of a cargo protein delivered by biotin-functionalized nanoparticles.

doi: 10.1016/j.actbio.2023.08.048

Figure Lengend Snippet: Fig. 2. In vivo Near Infrared Imaging following Subcutaneous Administration. C57/black mice were administered SA + saline, SA-bNP or bNP + saline SC into the right footpad ( n = 3 each group). Injection volume was 40 μL in each group through a 28G needle. SA was loaded onto bNPs by incubation with an approximately 2x molar excess of SA: bNP surface biotin for 30 minutes. Unbound SA was washed from particles by centrifugation and decanting supernatant 2x. SA + saline was injected at the calculated maximum biotin binding on bNPs. T = 0 SA + saline dose was higher than SA-bNP dose due to incomplete binding of SA on bNP and washing steps to remove unbound SA. Observed fluorescence in the 700 nm channel for SA + saline (A) and SA in SA-bNP (B), and in the 800nm channel for bNP in SA-bNP (C) and unloaded bNPs (D). Normalized injection site elimination profiles vs time for SA + Saline (E ), SA in SA-bNP (F) bNP in SA-bNP (G ), and bNP + saline (H). I, Elimination rate constants from injection site. Data was fitted to a 1-compartment PK model utilizing Matlab symbiology. J, Area under the curve for free and bound SA in the injection site were calculated from concentration vs time data. ∗, ∗∗, ∗∗∗p < 0.05, < 0.01, and < 0.001 respectively, by 1-way ANOVA or two-tailed T-test.

Article Snippet: Modeling and simulations MATLAB Simbiology 2018 (Natick, MA) module was utilized to imulate the elimination of SA and bNP from the SC injections.

Techniques: In Vivo, Imaging, Saline, Injection, Incubation, Centrifugation, Binding Assay, Concentration Assay, Two Tailed Test

Fig. 4. Modeling Lymph Node Occupancy from In Vivo Data up to 21 Days. Observed versus predicted concentration vs time curves fitted to the developed 2-compartment model utilizing MatLab symbiology for SA + saline footpad kinetics (A ), SA in SA-bNP footpad and dLN kinetics (B&C ), bNP + saline footpad kinetics (D ), and bNP in SA-bNP footpad and dLN kinetics (E&F).

Journal: Acta biomaterialia

Article Title: Modeling the kinetics of lymph node retention and exposure of a cargo protein delivered by biotin-functionalized nanoparticles.

doi: 10.1016/j.actbio.2023.08.048

Figure Lengend Snippet: Fig. 4. Modeling Lymph Node Occupancy from In Vivo Data up to 21 Days. Observed versus predicted concentration vs time curves fitted to the developed 2-compartment model utilizing MatLab symbiology for SA + saline footpad kinetics (A ), SA in SA-bNP footpad and dLN kinetics (B&C ), bNP + saline footpad kinetics (D ), and bNP in SA-bNP footpad and dLN kinetics (E&F).

Article Snippet: Modeling and simulations MATLAB Simbiology 2018 (Natick, MA) module was utilized to imulate the elimination of SA and bNP from the SC injections.

Techniques: In Vivo, Concentration Assay, Saline